Tanycyte-derived lactate activates astrocytic HCAR1 to modulate glutamatergic signaling and POMC neuron excitability

Proceedings of the National Academy of Sciences, Volume 123, Number 15, April 2026.
Significance How local metabolic signals in the brain are translated into adaptive feeding behavior remains a fundamental question in physiology. Here, we identify a glial metabolic relay in the hypothalamus, in which lactate produced by tanycytes…