A broad-spectrum inhibitor of copper-exporting P1B-type ATPases
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Proceedings of the National Academy of Sciences, Volume 123, Number 20, May 2026.
ImportanceCopper (Cu)-transporting P1B-type ATPases are essential for copper homeostasis in all domains of life, but they lack pharmacological inhibitors. This work identifies MKV3 as the first small molecule inhibiting Cu+-ATPases in bacteria, …
