A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceG protein–coupled receptors (GPCRs) transduce diverse physiological effects in different cell types. Many GPCRs are critical for neuromodulation, with their endogenous signaling in distinct neuronal circuits producing specific functional …