A conserved E3 ubiquitin ligase rewires carotenoid, sterol, and lipid metabolism in Xanthophyllomyces dendrorhous

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Proceedings of the National Academy of Sciences, Volume 123, Number 17, April 2026.
ImportanceEukaryotic cells must balance the biosynthesis of sterols, lipids, and, in many organisms, carotenoids, which rely on common precursors derived from acetyl-CoA. Our study identifies the ubiquitin ligase PTR1 as a regulator that coordinates these…

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