A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking

Proceedings of the National Academy of Sciences, Volume 122, Number 43, October 2025.
SignificanceBy presenting a conserved self-peptide to NKG2A/C-CD94 receptors on NK cells, non-polymorphic HLA-E plays a central role in the regulation of innate immunity. While HLA-E can also present foreign peptides to stimulate protective T cell responses,…