A J-domain protein enhances memory by promoting physiological amyloid formation in Drosophila

Proceedings of the National Academy of Sciences, Volume 123, Number 5, February 2026.
SignificanceAmyloid formation in the nervous system has until now been considered an unregulated and involuntary process. Here we report how nervous systems deploy amyloids in a controlled manner to facilitate memory. We have identified a member of the J domain…