A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment

Proceedings of the National Academy of Sciences, Volume 122, Number 52, December 2025.
SignificanceHypertrophic cardiomyopathy (HCM) is one of the leading genetic causes of sudden cardiac death in young individuals. Although often described as a hypercontractile disease, the molecular basis of this disease remains unclear, particularly for mutations with…