A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression

Proceedings of the National Academy of Sciences, Volume 122, Number 43, October 2025.
SignificanceA long-standing paradox in EZH2-driven cancer biology, particularly that observed in advanced prostate cancer, is how genes essential for tumor progression but silenced by EZH2 are reactivated. Here, we have identified a biomolecular…