BRAF inhibition increases TGFβ2 production and stimulates metastasis in mice with endogenous BRAFV600E-induced hepatocellular carcinoma

Proceedings of the National Academy of Sciences, Volume 122, Number 45, November 2025.
ImportanceThe mitogen-activated protein kinase–extracellular signal-regulated kinase (MEK-ERK) pathway is central in the development of hepatocellular carcinoma (HCC), but the impact of mutations in the rapidly accelerated fibrosarcoma B proto-oncogene, serine/…