Computational design of HLA class I superbinders for broad T cell immunogenicity

Proceedings of the National Academy of Sciences, Volume 123, Number 18, May 2026.
SignificanceHLA polymorphism poses a major challenge for the design of broadly effective T cell-based vaccines and immunotherapies. While most HLA-binding peptides bind to a single allele, “superbinding” peptides can engage multiple alleles on distinct HLAs…