An ADAR2-mimic base editor for efficient C-to-U RNA editing in vivo

Proceedings of the National Academy of Sciences, Volume 122, Number 45, November 2025.
Significance C-to-U RNA editing tools face several challenges, including simultaneous DNA mutations and large anchor domains associated with immunogenicity due to their microbial origin. To overcome these limitations, here we present AMBER (ADAR2-…