Anellovirus protein encoded by ORF2/3 functions as the viral replication initiation protein

Proceedings of the National Academy of Sciences, Volume 122, Number 52, December 2025.
Significance Anelloviruses (ANVs) are the most prevalent eukaryotic viruses in humans, but their molecular biology remains poorly understood due to the lack of experimental systems. Here, we identify a previously uncharacterized protein that we have called Rip (…