Atomic-level architecture and assembly mechanism of high-order structures of RIPK1 fibril revealed by integrated structural biology

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceProtein high-order assembly with a hierarchical organization is intrinsically difficult to study. To fully explore its functions and carry out further structure-based design, a thorough understanding of how the material is structured at the …