A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC

Proceedings of the National Academy of Sciences, Volume 122, Issue 27, July 2025. <br/>SignificanceAcquired drug resistance significantly undermines the clinical efficacy of BET inhibitors (BETi), underscoring the importance of elucidating the underlying mechanisms to advance their therapeutic development. In this study, we identified a …