Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. <br/>SignificanceCells must balance genome stability to prevent harmful genotoxic stress while allowing adaptation. Our study identifies ZNF93, a primate-specific transcription factor, as a key regulator of APOBEC3B, a mutagenic enzyme linked to cancer …