Cell wall remodeling–dependent morphotype switch in Mycobacterium avium differentially regulates colonization and tissue persistence

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceMycobacterium aviumcan switch between two primary colony morphologies—smooth transparent (SmT) and smooth opaque (SmO)—where SmT is associated with human disease while the avirulent SmO morphotype might represent an environmental form of the …