China’s innovation in translational medicine: rethinking early-stage clinical development

LEK Council. Advancing Innovation and Global Reach: The Next Chapter of China’s Clinical Trial Development https://www.lek.com/sites/default/files/insights/pdf-attachments/adv-innovation-global-china-ct-dev-report.pdf (2025).

Clarify. A decade of innovation, a decade to come. https://clarivate.com/life-sciences-healthcare/wp-content/uploads/sites/4/dlm_uploads/2024/11/Clarivate_10-years-of-Innovation-in-China_Report.pdf (2024).

Global data. Drug licensing for big pharma companies in China will reach a record 28% in 2024, GlobalData reveals. http://globaldata.com/media/business-fundamentals/large-pharma-drug-licensing-from-china-reaches-record-high-at-28-in-2024-reveals-globaldata/?utm_source=chatgpt.com (2025).

Beaney, A. OCT West Coast 2025: China overtakes the United States in annual number of clinical trials. Clinical Trials Arena https://www.clinicaltrialsarena.com/news/china-surpasses-us-for-annual-trials/?cf-view (February 12, 2025).

Liu, A. China Proposes Shorter Clinical Trial Reviews to Speed ​​Up Drug Development. Fierce biotechnology https://www.fiercebiotech.com/biotech/accelerate-drug-development-china-proposes-shorten-clinical-trial-review-time (June 16, 2025).

Wang, D. and Kroeber, A. The true Chinese model. Foreign Affairs https://www.foreignaffairs.com/china/real-china-model-wang-kroeber (2025).

Wang, Y. et al. Cerebrovascular vascular. Neurol. 4158-164 (2019).

Article PubMed PubMed Central Google Scholar

Cheng, S. et al. Cellular discovery. 975 (2023).

Article CAS PubMed PubMed Central Google Scholar

Wang, Y. et al. Preparation and application of fluorinated cilostazol derivatives. Chinese patent CN114685449B (2024).

Chen, L. et al. EUR. J. Neurol. 282893-2900 (2021).

Pun intended, FW et al. In front. Aging neurosciences. 14914017 (2022).

Article CAS PubMed PubMed Central Google Scholar

Insilico Medicine. Patient recruitment is complete for the clinical trial of 4B Technologies’ AI-discovered ALS drug, supported by Insilico Medicine. https://www.eurekalert.org/news-releases/1035782 (2024).

World Intellectual Property Organization. Patent Landscape Report: Generative Artificial Intelligence https://doi.org/10.34667/tind.49740 (WIPO, 2024).

Yang, Y., Husain, L. and Huang, Y. Global Health 2087 (2024).

Article PubMed PubMed Central Google Scholar

Wang, F., Ruan, DY and Xu, RH Cell 1871578-1583 (2024).

Article CAS PubMed Google Scholar

Tanchov, R. et al. ACS Pharmacol. Trans. Sci. 7586-613 (2024).

Article CAS PubMed PubMed Central Google Scholar

Xu, G. et al. Sig. Translate. Target. There. 10255 (2025).

Google Scholar article

AstuteAnalytica India Pvt. China’s exosome research product market is poised to reach a valuation of over US$148.93 million by 2032. ^(2024).

Verma, N. and Arora, S. Pharmaceuticals 17990 (2025).

Article PubMed PubMed Central Google Scholar

Eaton, ES At FDA Roundtable, Biotech Executives Call for “Modernizing” Regulations to Compete with China. FirstWord Pharma https://firstwordpharma.com/story/5970090 (June 6, 2025).

Gottlieb, S. How to Stop the Shift of Drug Discovery from the United States to China. https://www.statnews.com/2025/05/06/how-to-stop-the-shift-of-drug-discovery-from-the-us-to-china/ (May 6, 2025).

Gottlieb. South China’s advantage over American biotechnology has never been scientific. Washington Post https://www.washingtonpost.com/opinions/2025/09/22/gottlieb-fda-drugs-discovery-speed-china/ (2025).