Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Nav channels

Proceedings of the National Academy of Sciences, Volume 122, number 32, August 2025.
The sodium channels (NAV) of the significance of the will (Nav) are critical regulators of the excitability of the membrane and serve important therapeutic targets to treat arrhythmia, epilepsy and pain. Nav1.5, NAV1.8 and NAV1.9, which cannot be blocked by tetrodotoxin (…