CryoEM structure of ALK2:BMP6 reveals distinct mechanism that allow ALK2 to interact with both BMP and activin ligands

Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. <br/>SignificanceActivin receptor-like kinase-2 interacts with two different classes of transforming growth factor β ligands: the Bone Morphogenetic Proteins (BMPs) and the activins. With BMP ligands, ALK2 signals to play roles in bone modeling, while with …