DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 123, Number 18, May 2026.
SignificanceThe tumor suppressor p53, a central gatekeeper against malignant transformation, is inactivated by mutation in approximately half of all human cancers. Many p53 mutants are temperature sensitive (TS), yet exhibit reduced conformational stability…
