Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids

Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis study establishes a pathogenic circuit framework to conceptualize the pathophysiology of nonlytic viral infections. Using hepatitis E virus (HEV) and macrophage-augmented organoids as an innovative experimental system, we delineate three …