Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
Importance This study identifies rare deleterious variants in the POLR3A and POLR3C genes encoding RNA polymerase III (POL III), a cytosolic DNA sensor, in patients with critical COVID-19, revealing impaired responses to type I interferon. Mechanistically, we…
