Droplet growth, Ostwald’s rule, and emergence of order in Fused in Sarcoma

Proceedings of the National Academy of Sciences, Volume 123, Number 4, January 2026.
SignificanceThe unstructured portion of an RNA-binding protein (FUS-LC) that undergoes phase separation has three regions that form mutually exclusive non-polymorphic crossover β-cores. The C-terminal core (core-3) forms first, while the fibril forming core-2…