Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells

Proceedings of the National Academy of Sciences, Volume 122, Number 48, December 2025.
SignificanceHere, we performed a drug repurposing screen that identified compounds that selectively activate the integrated stress response (ISR) via the OMA1-DELE1-HRI signaling axis. Using these compounds, and another ISR activator compound that…