Endogenous forms of ATP–ATP4− and MgATP2−—orchestrate distinct pathophysiological signaling via biased activation of P2X3 receptors

Proceedings of the National Academy of Sciences, Volume 122, Number 50, December 2025.
ImportanceOur study reveals a mechanism of activation of P2X3 receptors by their endogenous ligands, MgATP2− and ATP4−. Although they share the same orthosteric binding site, these ligands activate the receptor through distinct pathways, producing different…