Exploring PrPC unfolding as a critical step preceding its refolding in the context of PrPSc propagation

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificanceElucidation of the structure of PrPSchas opened the possibility to understand propagation of this quintessential prion. However, PrPScis a standard amyloid made of flat stacked monomers. Therefore, its templating surface can easily direct …