Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems

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Proceedings of the National Academy of Sciences, Volume 123, Number 10, March 2026.
ImportanceFear extinction, the process that underlies exposure therapy for anxiety disorders, may inadvertently worsen fear generalization, when fear spreads to safe situations. We found that in mice, extinction training triggers overactivation of a brain…

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