Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis

Proceedings of the National Academy of Sciences, Volume 123, Issue 19, May 2026. <br/>SignificanceGenetic mutations often play different roles in cancer, driving or suppressing tumor growth depending on their molecular context. The protein Speckle-type POZ protein (SPOP) is a striking example that acts as either a tumor-suppressor or …