Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceContraction of resistance arteries in peripheral tissues maintains blood pressure (BP) and facilitates cardiac output distribution according to local metabolic demands. Sphingosine 1-phosphate (S1P) is a signaling lipid that is released from …