Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
SignificanceRMRPadopts distinct Mg2+-dependent conformations and interacts with the DEAD-box helicases DDX5 and DDX3X, which display different binding affinities and unwinding activities. DDX5 and DDX3X are crucial for RMRP mitochondrial localization and…