Immune cells employ intermittent integrin-mediated traction forces for 3D migration

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
Significance This study challenges the long-held notion that immune cells migrate through tissues without grasping the surrounding matrix, relying on a friction-based mode of amoeboid migration. We show that when confronted with restricted spaces within 3D matrices,…