Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity

Proceedings of the National Academy of Sciences, Volume 122, Issue 32, August 2025. <br/>SignificanceImmune-responsive gene 1 (Irg1) was identified as a significantly elevated gene under inflammatory conditions through in vitro and in vivo models. Using global knockout (KO) mice, we identifiedIrg1as a protective endogenous gene that …