In situ and real-time monitoring of intracellular activities in single live cells using a nanopore probe

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceUnderstanding molecular dynamics within single live cells is essential for elucidating how cellular heterogeneity drives physiology and disease. Yet, existing single-cell methods cannot continuously track multiple biomolecules in situ and in …