Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock

Proceedings of the National Academy of Sciences, Volume 122, Issue 29, July 2025. <br/>SignificancePhosphoinositide 3-kinases (PI3Ks) phosphorylate the head group of phosphoinositide lipids in the cytoplasmic leaflet of subcellular membranes and thereby regulate signaling and membrane dynamics. The class II PI3K-C2α isoform has recently …