Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex
Proceedings of the National Academy of Sciences, volume 122, number 24, June 2025.
Significant significant (a disintegrin and metalloproteinase) -17 is a crucial enzyme that activates the proteins involved in the development, immune defense and fabrics. Its deregulation is linked to diseases such as cancer, autoimmune conditions and COVID-19. …
