Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex

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Proceedings of the National Academy of Sciences, volume 122, number 24, June 2025.
Significant significant (a disintegrin and metalloproteinase) -17 is a crucial enzyme that activates the proteins involved in the development, immune defense and fabrics. Its deregulation is linked to diseases such as cancer, autoimmune conditions and COVID-19. …

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