Aducanumab binding to Aβ1-42 fibrils alters dynamics of the N-terminal tail while preserving the fibril core

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificanceUnderstanding how therapeutic antibodies interact with amyloid-β (Aβ) fibrils is crucial for developing effective Alzheimer’s disease treatments. Magic-angle spinning NMR provides atomic-level insights into the binding of aducanumab to mature …