LRBA organizes distinct vesicular trafficking systems in distal nephron segments for water and sodium conservation

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificanceLipopolysaccharide-responsive and beige-like anchor protein (LRBA)-deficient patients are at high risk of dehydration due to chronic diarrhea and recurrent infections; however, approximately 20% of patients in a multicenter registry also …