mGluR1 signaling is necessary for strengthening winner climbing fiber inputs in the developing mouse cerebellum

Proceedings of the National Academy of Sciences, Volume 123, Number 4, January 2026.
ImportancePrecise formation of neural circuits relies on both the selective strengthening of frequently used synaptic inputs and the elimination of redundant connections. In cerebellar Purkinje cells, reinforcement of a single “winning” climbing fiber (…