Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificancePancreatic ductal adenocarcinoma (PDAC) is a major unmet medical need: The standard of care for these patients has not changed in decades, life expectancy is abysmal, and more effective therapies are yet to be discovered. We now find that PDAC …