Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation

Proceedings of the National Academy of Sciences, Volume 122, number 30, July 2025.
Cellular DNA is wrapped around an octamer composed of four histone proteins forming the fundamental unity of the structure of chromatin, the nucleosome nucleus particle (NCP). The intrinsically disorderly tails of histones serve as scaffolding to link a painting …