Monitoring of plasma and urine tumor-derived DNA to inform bladder-sparing approaches for patients with muscle-invasive bladder cancer

Proceedings of the National Academy of Sciences, Volume 123, Issue 8, February 2026. <br/>SignificanceRadical cystectomy—surgical removal of the bladder and creation of permanent urinary diversion—has historically been used to treat muscle-invasive bladder cancer, but is life-altering with permanent changes to urinary function, sexuality, and …