Monkeypox virus protein OPG188 antagonizes cGAS–STING antiviral signaling pathway to mediate immune evasion

Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceThis study identifies key monkeypox virus (MPXV) immune evasion proteins—OPG147, OPG188, and OPG200—that suppress the host cGAS–STING antiviral pathway. We characterize OPG188 as a nuclease that degrades the immune signaling molecule 2′3′-…