Multiple modes of AFM reveal distinct mechanical properties for dystrophin and utrophin not manifest by small fragments

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceDuchenne muscular dystrophy (DMD) is a lethal muscle wasting disorder caused by loss of the protein dystrophin. Utrophin is a fetal homologue of dystrophin that is under active investigation as a dystrophin replacement therapy for DMD. However,…