Negative interplay between HIV-1 Gag and amyloid precursor protein centers around competition for VPS4A and TSG101

Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. <br/>SignificanceMacrophages and microglia act as reservoirs for HIV-1, including in the brain where infection is associated with neurocognitive disorders. We recently showed that HIV-1 promotes the ubiquitination of the amyloidogenic C-terminal fragment of …