NFL DFS picks, lineup advice for Sunday main slate from daily Fantasy football optimizer tool
Developing a successful NFL DFS strategy can take many forms, but one of the most common approaches is to focus on games with the highest projected point totals when identifying top NFL DFS picks and creating NFL DFS stacks. The highest NFL Week 7 plus/minus for Sunday’s main slate is 54.5 in the Cowboys vs. Commanders game. Other potential high-scoring matchups on Sunday include Colts vs. Chargers (over/under 48.5), Saints vs. Bears (over/under 46.5) and Raiders vs. Chiefs (over/under 45.5). So, you can expect stars like Dak Prescott, Jayden Daniels, Jonathan Taylor, Ladd McConkey and Travis Kelce to be main players on many NFL DFS rosters.
However, players of this caliber will lower your NFL DFS salary cap, forcing you to look for more potential NFL DFS sleepers and NFL DFS values. Should players like Daniel Jones or Justin Herbert force their way into your quarterback spot for Sunday’s main roster? Will underperforming players like Saquon Barkley and Tua Tagovailoa finally live up to their price tags on NFL DFS sites? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS lineup optimizer.
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The DFS Optimizer uses information from the SportsLine Advanced Data Projection Model and professional DFS millionaire Mike McClure to identify the best DFS picks/plays for any list of betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and create winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups with confidence with injury updates, floor and ceiling player projections, and Vegas lines and picks, all in one winning tool for sports betting apps.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 6 schedule and has just locked in its best daily fantasy football lineups. You can only see his optimal lineups on SportsLine.
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Best NFL Week 7 DFS Picks for Sunday
One of the optimizer’s top DFS value picks for Sunday is Patriots quarterback Drake Maye ($6,300 on DraftKings and $8,200 on FanDuel). The former first-round pick out of North Carolina had a solid rookie season in 2024, as he threw for 2,276 yards with 15 touchdowns and 10 interceptions, and a passer rating of 88.1. He also added 421 rushing yards and two rushing touchdowns on 54 attempts, demonstrating his mobility and balance under pressure.
In 2025, Maye took a big step forward, totaling 1,522 yards with 10 touchdowns and just two interceptions while completing over 73% of his throws. His improved accuracy and decision-making helped the Patriots offense become more efficient and balanced. Maye showed impressive command of the playbook and confidence in the pocket, reducing turnovers while continuing to attack downfield. See who else to choose here.
The optimizer’s NFL DFS strategy also includes Cowboys running back Javonte Williams’ roster ($6,700 on DraftKings and $7,500 on FanDuel). The former second-round pick out of North Carolina signed with the Cowboys this past offseason after spending the first four years of his career with the Denver Broncos. Williams suffered several injuries during his career in Denver, but still managed to total 2,394 yards and 11 touchdowns and catch 158 passes for 966 yards and five scores in 54 games.
Williams has enjoyed a resurgence in Dallas, totaling 92 carries for 476 yards and five touchdowns in six games. He also contributed 22 receptions for 83 yards and a receiving score, proving to be a reliable dual-threat option. Williams has shown renewed momentum and confidence in Dallas’ offense, thriving behind a strong offensive line. You can see the rest of the optimizer’s NFL DFS picks here.
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How to Create Week 7 Sunday NFL DFS Lineups
The NFL DFS Optimizer also targets several undervalued players who could explode in big numbers on Sunday. These players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are and the rest of the optimizer’s NFL DFS picks at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see the optimal NFL DFS picks, rankings, tips and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.
