NIPBL and STAG1 enable loop extrusion by providing differential DNA–cohesin affinity

Proceedings of the National Academy of Sciences, Volume 122, number 32, August 2025.
Significant extrusion has emerged as a fundamental process to maintain the structure and dynamics of chromosomes. Molecular heterogeneity and cooperative effects within a multi -component biomolecular machine modulated by ATP complicate the quantification of …