Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability

Proceedings of the National Academy of Sciences, Volume 122, number 34, August 2025.
Significant homostasis in complex animals requires multiple sensory mechanisms to integrate autonomous actions of cells with tissue and system feedback circuits. The 2-aminoethanethiol dioxygenase (teenager), catalyzed n-degret proteolysis is fast, …