Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 31 topology

Proceedings of the National Academy of Sciences, Volume 123, Issue 17, April 2026. <br/>SignificanceWe present the crystal structures of proteins adopting the Knotted Solenoid fold, a solenoidal architecture uniquely capable of forming a 31knot through a “skip-and-backtrack” shift, challenging the assumption that allβ-solenoid proteins are …