Nucleotide- and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA

Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. <br/>SignificanceArsenic toxicity arises from the ability of trivalent arsenite to tightly bind thiol groups, thus disrupting cellular processes. Many bacteria can detoxify arsenite via efflux through the membrane transporter ArsB. In some species, a …